FRAT1 (FRAT regulator of WNT signaling pathway 1)

2003-02-01  

Identity

HGNC
LOCATION
10q24.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10023
MIM: 602503
HGNC: 3944
Ensembl: ENSG00000165879

Variants:

dbSNP: 10023
ClinVar: 10023
TCGA: ENSG00000165879
COSMIC: FRAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165879ENST00000371021Q92837

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Beta-catenin phosphorylation cascadeREACTOMER-HSA-196299
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Disassembly of the destruction complex and recruitment of AXIN to the membraneREACTOMER-HSA-4641262
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
248291512014The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.37
125565192003Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.29
164792542006Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours.14
184981362008FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma.13
218186392011Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer.12
225289422012Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC.12
236138132013Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion.12
200413152011FRAT1 expression and its correlation with pathologic grade, proliferation, and apoptosis in human astrocytomas.11
200966702010The expression profile of FRAT1 in human gliomas.11

Citation

Dessen P

FRAT1 (FRAT regulator of WNT signaling pathway 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/464/frat1