FRMD6 (FERM domain containing 6)

2012-05-01  

Identity

HGNC
LOCATION
14q22.1
LOCUSID
ALIAS
C14orf31,EX1,Willin,c14_5320
FUSION GENES

Other Information

Locus ID:

NCBI: 122786
MIM: 614555
HGNC: 19839
Ensembl: ENSG00000139926

Variants:

dbSNP: 122786
ClinVar: 122786
TCGA: ENSG00000139926
COSMIC: FRMD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139926ENST00000344768Q96NE9
ENSG00000139926ENST00000356218Q96NE9
ENSG00000139926ENST00000395718Q96NE9
ENSG00000139926ENST00000553556Q96NE9
ENSG00000139926ENST00000554778G3V517
ENSG00000139926ENST00000555197H0YJC1
ENSG00000139926ENST00000555703G3V2L4
ENSG00000139926ENST00000557405H0YJ19

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
216667192012Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.38
221904282012Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.15
217854622012Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway.14
280798912017CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.10
161376812005A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.9
276611202016FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases.4
311289102019MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway.0
319179932020The tumor suppressive effect of long non-coding RNA FRMD6-AS2 in uteri corpus endometrial carcinoma.0

Citation

Dessen P

FRMD6 (FERM domain containing 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52707/frmd6