FSHB (follicle stimulating hormone subunit beta)

2008-10-01  

Identity

HGNC
LOCATION
11p14.1
LOCUSID
ALIAS
HH24

Other Information

Locus ID:

NCBI: 2488
MIM: 136530
HGNC: 3964
Ensembl: ENSG00000131808

Variants:

dbSNP: 2488
ClinVar: 2488
TCGA: ENSG00000131808
COSMIC: FSHB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131808ENST00000254122P01225
ENSG00000131808ENST00000254122A0A0F7RQE8
ENSG00000131808ENST00000417547P01225
ENSG00000131808ENST00000417547A0A0F7RQE8
ENSG00000131808ENST00000533718P01225
ENSG00000131808ENST00000533718A0A0F7RQE8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
GnRH signaling pathwayKEGGko04912
Neuroactive ligand-receptor interactionKEGGhsa04080
GnRH signaling pathwayKEGGhsa04912
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
186537052008Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity.48
193249682009A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription.38
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
202337862010FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes.34
152718742004Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor.33
211497142010Follicle-stimulating hormone increases bone mass in female mice.28
170790722007All-or-none N-glycosylation in primate follicle-stimulating hormone beta-subunits.26
206341972010Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.25
185678942008FSHB promoter polymorphism within evolutionary conserved element is associated with serum FSH level in men.24

Citation

Dessen P

FSHB (follicle stimulating hormone subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50404/fshb