Identity
HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
FHC,FTH,FTHL6,HFE5,PIG15,PLIF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2495
MIM: 134770
HGNC: 3976
Ensembl: ENSG00000167996
Variants:
dbSNP: 2495
ClinVar: 2495
TCGA: ENSG00000167996
COSMIC: FTH1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37265023 | 2024 | Distribution of ferritin complex in the adult brain and altered composition in neuroferritinopathy due to a novel variant in the ferritin heavy chain gene FTH1 (c.409_410del; p.H137Lfs*4). | 1 |
| 38040806 | 2024 | M(7)G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma. | 3 |
| 38499786 | 2024 | Ferritin heavy chain supports stability and function of the regulatory T cell lineage. | 0 |
| 38609896 | 2024 | FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation. | 0 |
| 38738555 | 2024 | METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer. | 0 |
| 37265023 | 2024 | Distribution of ferritin complex in the adult brain and altered composition in neuroferritinopathy due to a novel variant in the ferritin heavy chain gene FTH1 (c.409_410del; p.H137Lfs*4). | 1 |
| 38040806 | 2024 | M(7)G modification of FTH1 and pri-miR-26a regulates ferroptosis and chemotherapy resistance in osteosarcoma. | 3 |
| 38499786 | 2024 | Ferritin heavy chain supports stability and function of the regulatory T cell lineage. | 0 |
| 38609896 | 2024 | FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation. | 0 |
| 38738555 | 2024 | METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer. | 0 |
| 36913375 | 2023 | RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability. | 1 |
| 36940732 | 2023 | WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. | 1 |
| 37011414 | 2023 | AKT1 participates in ferroptosis vulnerability by driving autophagic degradation of FTH1 in cisplatin-resistant ovarian cancer. | 4 |
| 37304234 | 2023 | LncRNA CACNA1G-AS1 up-regulates FTH1 to inhibit ferroptosis and promote malignant phenotypes in ovarian cancer cells. | 9 |
| 37528314 | 2023 | NSUN5-FTH1 Axis Inhibits Ferroptosis to Promote the Growth of Gastric Cancer Cells. | 1 |
Citation
Dessen P
FTH1 (ferritin heavy chain 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46107/fth1
