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FTO (FTO alpha-ketoglutarate dependent dioxygenase)

Identity

Alias_namesfat mass and obesity associated
FTO, alpha-ketoglutarate dependent dioxygenase
Alias_symbol (synonym)KIAA1752
MGC5149
ALKBH9
Other aliasBMIQ14
GDFD
HGNC (Hugo) FTO
LocusID (NCBI) 79068
Atlas_Id 51352
Location 16q12.2  [Link to chromosome band 16q12]
Location_base_pair Starts at 53703963 and ends at 54114467 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTN4 (19q13.2) / FTO (16q12.2)FTO (16q12.2) / KIAA0430 (16p13.11)FTO (16q12.2) / RBL2 (16q12.2)
FTO (16q12.2) / ZNF536 (19q12)PHIP (6q14.1) / FTO (16q12.2)UGT2B7 (4q13.2) / FTO (16q12.2)
ACTN4 19q13.2 / FTO 16q12.2FTO 16q12.2 / RBL2 16q12.2FTO 16q12.2 / ZNF536 19q12
PHIP 6q14.1 / FTO 16q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(6;16)(q14;q12) PHIP/FTO
FTO/RBL2 (16q12)
t(16;16)(q12;q13) FTO/HERPUD1
t(16;19)(q12;q12) FTO/ZNF536
t(16;19)(q12;q13) ACTN4/FTO

External links

Nomenclature
HGNC (Hugo)FTO   24678
Cards
Entrez_Gene (NCBI)FTO  79068  FTO alpha-ketoglutarate dependent dioxygenase
AliasesALKBH9; BMIQ14; GDFD
GeneCards (Weizmann)FTO
Ensembl hg19 (Hinxton)ENSG00000140718 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140718 [Gene_View]  ENSG00000140718 [Sequence]  chr16:53703963-54114467 [Contig_View]  FTO [Vega]
ICGC DataPortalENSG00000140718
TCGA cBioPortalFTO
AceView (NCBI)FTO
Genatlas (Paris)FTO
WikiGenes79068
SOURCE (Princeton)FTO
Genetics Home Reference (NIH)FTO
Genomic and cartography
GoldenPath hg38 (UCSC)FTO  -     chr16:53703963-54114467 +  16q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FTO  -     16q12.2   [Description]    (hg19-Feb_2009)
GoldenPathFTO - 16q12.2 [CytoView hg19]  FTO - 16q12.2 [CytoView hg38]
ImmunoBaseENSG00000140718
Mapping of homologs : NCBIFTO [Mapview hg19]  FTO [Mapview hg38]
OMIM610966   612460   612938   
Gene and transcription
Genbank (Entrez)AB051539 AK096554 AK295196 BC001284 BC003583
RefSeq transcript (Entrez)NM_001080432 NM_001363891 NM_001363894 NM_001363896 NM_001363897 NM_001363898 NM_001363899 NM_001363900 NM_001363901 NM_001363903 NM_001363905 NM_001363988
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FTO
Cluster EST : UnigeneHs.528833 [ NCBI ]
CGAP (NCI)Hs.528833
Alternative Splicing GalleryENSG00000140718
Gene ExpressionFTO [ NCBI-GEO ]   FTO [ EBI - ARRAY_EXPRESS ]   FTO [ SEEK ]   FTO [ MEM ]
Gene Expression Viewer (FireBrowse)FTO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79068
GTEX Portal (Tissue expression)FTO
Human Protein AtlasENSG00000140718-FTO [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0B1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0B1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0B1
Splice isoforms : SwissVarQ9C0B1
Catalytic activity : Enzyme1.14.11.- [ Enzyme-Expasy ]   1.14.11.-1.14.11.- [ IntEnz-EBI ]   1.14.11.- [ BRENDA ]   1.14.11.- [ KEGG ]   
PhosPhoSitePlusQ9C0B1
Domains : Interpro (EBI)AlkB-like_sf    FTO    FTO_C    FTO_C_sf    FTO_cat_dom   
Domain families : Pfam (Sanger)FTO_CTD (PF12934)    FTO_NTD (PF12933)   
Domain families : Pfam (NCBI)pfam12934    pfam12933   
Domain families : Smart (EMBL)FTO_NTD (SM01223)  
Conserved Domain (NCBI)FTO
DMDM Disease mutations79068
Blocks (Seattle)FTO
PDB (RSDB)3LFM    4CXW    4CXX    4CXY    4IDZ    4IE0    4IE4    4IE5    4IE6    4IE7    4QHO    4QKN    4ZS2    4ZS3    5DAB    5F8P   
PDB Europe3LFM    4CXW    4CXX    4CXY    4IDZ    4IE0    4IE4    4IE5    4IE6    4IE7    4QHO    4QKN    4ZS2    4ZS3    5DAB    5F8P   
PDB (PDBSum)3LFM    4CXW    4CXX    4CXY    4IDZ    4IE0    4IE4    4IE5    4IE6    4IE7    4QHO    4QKN    4ZS2    4ZS3    5DAB    5F8P   
PDB (IMB)3LFM    4CXW    4CXX    4CXY    4IDZ    4IE0    4IE4    4IE5    4IE6    4IE7    4QHO    4QKN    4ZS2    4ZS3    5DAB    5F8P   
Structural Biology KnowledgeBase3LFM    4CXW    4CXX    4CXY    4IDZ    4IE0    4IE4    4IE5    4IE6    4IE7    4QHO    4QKN    4ZS2    4ZS3    5DAB    5F8P   
SCOP (Structural Classification of Proteins)3LFM    4CXW    4CXX    4CXY    4IDZ    4IE0    4IE4    4IE5    4IE6    4IE7    4QHO    4QKN    4ZS2    4ZS3    5DAB    5F8P   
CATH (Classification of proteins structures)3LFM    4CXW    4CXX    4CXY    4IDZ    4IE0    4IE4    4IE5    4IE6    4IE7    4QHO    4QKN    4ZS2    4ZS3    5DAB    5F8P   
SuperfamilyQ9C0B1
Human Protein Atlas [tissue]ENSG00000140718-FTO [tissue]
Peptide AtlasQ9C0B1
IPIIPI00028277   IPI00845477   IPI00845224   IPI00945698   IPI00876966   IPI00981141   IPI00945989   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0B1
IntAct (EBI)Q9C0B1
FunCoupENSG00000140718
BioGRIDFTO
STRING (EMBL)FTO
ZODIACFTO
Ontologies - Pathways
QuickGOQ9C0B1
Ontology : AmiGOtemperature homeostasis  nucleus  nucleus  nucleoplasm  cytoplasm  DNA dealkylation involved in DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  ferrous iron binding  regulation of lipid storage  nuclear speck  transferase activity  oxidative RNA demethylase activity  oxidative DNA demethylase activity  oxidative DNA demethylase activity  oxidative single-stranded DNA demethylation  oxidative single-stranded DNA demethylation  oxidative single-stranded RNA demethylation  oxidative single-stranded RNA demethylation  oxidative single-stranded RNA demethylation  regulation of multicellular organism growth  RNA repair  DNA-N1-methyladenine dioxygenase activity  DNA-N1-methyladenine dioxygenase activity  regulation of respiratory system process  adipose tissue development  mRNA destabilization  regulation of white fat cell proliferation  oxidative demethylation  DNA demethylation  regulation of brown fat cell differentiation  RNA N6-methyladenosine dioxygenase activity  RNA N6-methyladenosine dioxygenase activity  RNA N6-methyladenosine dioxygenase activity  tRNA demethylase activity  
Ontology : EGO-EBItemperature homeostasis  nucleus  nucleus  nucleoplasm  cytoplasm  DNA dealkylation involved in DNA repair  DNA dealkylation involved in DNA repair  ferrous iron binding  ferrous iron binding  regulation of lipid storage  nuclear speck  transferase activity  oxidative RNA demethylase activity  oxidative DNA demethylase activity  oxidative DNA demethylase activity  oxidative single-stranded DNA demethylation  oxidative single-stranded DNA demethylation  oxidative single-stranded RNA demethylation  oxidative single-stranded RNA demethylation  oxidative single-stranded RNA demethylation  regulation of multicellular organism growth  RNA repair  DNA-N1-methyladenine dioxygenase activity  DNA-N1-methyladenine dioxygenase activity  regulation of respiratory system process  adipose tissue development  mRNA destabilization  regulation of white fat cell proliferation  oxidative demethylation  DNA demethylation  regulation of brown fat cell differentiation  RNA N6-methyladenosine dioxygenase activity  RNA N6-methyladenosine dioxygenase activity  RNA N6-methyladenosine dioxygenase activity  tRNA demethylase activity  
NDEx NetworkFTO
Atlas of Cancer Signalling NetworkFTO
Wikipedia pathwaysFTO
Orthology - Evolution
OrthoDB79068
GeneTree (enSembl)ENSG00000140718
Phylogenetic Trees/Animal Genes : TreeFamFTO
HOGENOMQ9C0B1
Homologs : HomoloGeneFTO
Homology/Alignments : Family Browser (UCSC)FTO
Gene fusions - Rearrangements
Fusion : MitelmanACTN4/FTO [19q13.2/16q12.2]  [t(16;19)(q12;q13)]  
Fusion : MitelmanFTO/RBL2 [16q12.2/16q12.2]  [t(16;16)(q12;q12)]  
Fusion : MitelmanFTO/ZNF536 [16q12.2/19q12]  [t(16;19)(q12;q12)]  
Fusion : MitelmanPHIP/FTO [6q14.1/16q12.2]  [t(6;16)(q14;q12)]  
Fusion PortalACTN4 19q13.2 FTO 16q12.2 BRCA
Fusion PortalFTO 16q12.2 RBL2 16q12.2 LUAD
Fusion PortalFTO 16q12.2 ZNF536 19q12 HNSC
Fusion PortalPHIP 6q14.1 FTO 16q12.2 LUAD
Fusion : QuiverFTO
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFTO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FTO
dbVarFTO
ClinVarFTO
1000_GenomesFTO 
Exome Variant ServerFTO
ExAC (Exome Aggregation Consortium)ENSG00000140718
GNOMAD BrowserENSG00000140718
Varsome BrowserFTO
Genetic variants : HAPMAP79068
Genomic Variants (DGV)FTO [DGVbeta]
DECIPHERFTO [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFTO 
Mutations
ICGC Data PortalFTO 
TCGA Data PortalFTO 
Broad Tumor PortalFTO
OASIS PortalFTO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFTO  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFTO
Mutations and Diseases : HGMDFTO
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FTO
DgiDB (Drug Gene Interaction Database)FTO
DoCM (Curated mutations)FTO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FTO (select a term)
intoGenFTO
Cancer3DFTO(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610966    612460    612938   
Orphanet18689   
DisGeNETFTO
MedgenFTO
Genetic Testing Registry FTO
NextProtQ9C0B1 [Medical]
TSGene79068
GENETestsFTO
Target ValidationFTO
Huge Navigator FTO [HugePedia]
snp3D : Map Gene to Disease79068
BioCentury BCIQFTO
ClinGenFTO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79068
Chemical/Pharm GKB GenePA152208656
Clinical trialFTO
Miscellaneous
canSAR (ICR)FTO (select the gene name)
DataMed IndexFTO
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFTO
EVEXFTO
GoPubMedFTO
iHOPFTO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:44:04 CET 2019
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