FUCA2 (alpha-L-fucosidase 2)

2014-11-01  

Identity

HGNC
LOCATION
6q24.2
LOCUSID
ALIAS
dJ20N2.5
FUSION GENES

Other Information

Locus ID:

NCBI: 2519
MIM: 136820
HGNC: 4008
Ensembl: ENSG00000001036

Variants:

dbSNP: 2519
ClinVar: 2519
TCGA: ENSG00000001036
COSMIC: FUCA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000001036ENST00000002165Q9BTY2
ENSG00000001036ENST00000451668Q7Z6V2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Other glycan degradationKEGGko00511
Other glycan degradationKEGGhsa00511
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196664782009Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells.20
185218982008Serum fucosylation changes in oral cancer and oral precancerous conditions: alpha-L-fucosidase as a marker.18
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
244694682014Modulation of expression in BEAS-2B airway epithelial cells of α-L-fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of α-L-fucosidase 2.2
276363712016Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease.2

Citation

Dessen P

FUCA2 (alpha-L-fucosidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63626/fuca2