FUT4 (fucosyltransferase 4)

2007-11-01  

Identity

HGNC
LOCATION
11q21
LOCUSID
ALIAS
CD15,ELFT,FCT3A,FUC-TIV,FUTIV,LeX,SSEA-1

Other Information

Locus ID:

NCBI: 2526
MIM: 104230
HGNC: 4015
Ensembl: ENSG00000196371

Variants:

dbSNP: 2526
ClinVar: 2526
TCGA: ENSG00000196371
COSMIC: FUT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196371ENST00000358752P22083

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191858482009Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.126
195721482010Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14⁻/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer.103
197251192009CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells.74
219317652011MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma.67
218576692011In vitro generation of human cells with cancer stem cell properties.56
201812612010CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors.42
266365412016Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4.39
155794662005Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII.26
204587272010Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells.25
204587272010Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells.25

Citation

Dessen P

FUT4 (fucosyltransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49792/fut4