FXR1 (FMR1 autosomal homolog 1)

2007-06-01  

Identity

HGNC
LOCATION
3q26.33
LOCUSID
ALIAS
FXR1P,MYOPMIL,MYORIBF
FUSION GENES

Other Information

Locus ID:

NCBI: 8087
MIM: 600819
HGNC: 4023
Ensembl: ENSG00000114416

Variants:

dbSNP: 8087
ClinVar: 8087
TCGA: ENSG00000114416
COSMIC: FXR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114416ENST00000305586P51114
ENSG00000114416ENST00000357559P51114
ENSG00000114416ENST00000445140P51114
ENSG00000114416ENST00000465551C9IZ22
ENSG00000114416ENST00000468861E7EU85
ENSG00000114416ENST00000469882C9JZE0
ENSG00000114416ENST00000480918B4DXZ6
ENSG00000114416ENST00000482125H7C4S4
ENSG00000114416ENST00000484042C9JAJ4
ENSG00000114416ENST00000484790C9J5B4
ENSG00000114416ENST00000484958C9JY20
ENSG00000114416ENST00000491062E9PFF5
ENSG00000114416ENST00000491674C9JYQ6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173828802007AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.237
194873682009Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.49
204422042010Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.35
257338522015The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers.31
172903962007Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung.29
210721622010Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.29
186283142008Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients.28
235552842013A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability.25
276068792016RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC.23
269426792016A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence.21

Citation

Dessen P

FXR1 (FMR1 autosomal homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47559/fxr1