FYB1 (FYN binding protein 1)

2010-05-01  

Identity

HGNC
FYB1
LOCATION
5p13.1
LOCUSID
2533
ALIAS
ADAP,FYB,PRO0823,SLAP-130,SLAP130,THC3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2533
MIM: 602731
HGNC: 4036
Ensembl: ENSG00000082074

Variants:

dbSNP: 2533
ClinVar: 2533
TCGA: ENSG00000082074
COSMIC: FYB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082074ENST00000351578O15117
ENSG00000082074ENST00000506557D6RAE8
ENSG00000082074ENST00000509072D6RC38
ENSG00000082074ENST00000510188D6RFJ5
ENSG00000082074ENST00000512138D6RER7
ENSG00000082074ENST00000512982O15117
ENSG00000082074ENST00000515010O15117
ENSG00000082074ENST00000646045O15117
ENSG00000082074ENST00000646444A0A2R8YEE1

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
158491952005Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.33
215366502011Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.27
245232372014ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.25
177857902007Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival.23
201641712010NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein.21
239795962013Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.20
188020882008Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.18
158430312005The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain.13
175114752007Redox-regulated conformational changes in an SH3 domain.10

Citation

Dessen P

FYB1 (FYN binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51500/fyb1