FYN (FYN proto-oncogene, Src family tyrosine kinase)

2003-02-01 Affiliation

Identity

HGNC

FYN

LOCATION

6q21

LOCUSID

2534

ALIAS

SLK,SYN,p59-FYN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2534
MIM: 137025
HGNC: 4037
Ensembl: ENSG00000010810

Variants:

dbSNP: 2534
ClinVar: 2534
TCGA: ENSG00000010810
COSMIC: FYN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000010810	ENST00000229471	P06241
ENSG00000010810	ENST00000354650	P06241
ENSG00000010810	ENST00000368667	P06241
ENSG00000010810	ENST00000368678	P06241
ENSG00000010810	ENST00000368682	P06241
ENSG00000010810	ENST00000462598	E5RHX7
ENSG00000010810	ENST00000462856	E5RFS5
ENSG00000010810	ENST00000484067	E5RK23
ENSG00000010810	ENST00000487824	E5RJX7
ENSG00000010810	ENST00000517419	E5RH71
ENSG00000010810	ENST00000518295	E5RGT0
ENSG00000010810	ENST00000518630	E5RHF7
ENSG00000010810	ENST00000520518	E5RIX5
ENSG00000010810	ENST00000521062	E5RFM6
ENSG00000010810	ENST00000523238	E5RFM0
ENSG00000010810	ENST00000523570	E5RFM4
ENSG00000010810	ENST00000523574	E5RGM6
ENSG00000010810	ENST00000524310	E5RI25
ENSG00000010810	ENST00000538466	P06241

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Focal adhesion	KEGG	ko04510
Adherens junction	KEGG	ko04520
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
Fc epsilon RI signaling pathway	KEGG	ko04664
Pathogenic Escherichia coli infection	KEGG	ko05130
Axon guidance	KEGG	hsa04360
Focal adhesion	KEGG	hsa04510
Adherens junction	KEGG	hsa04520
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
Fc epsilon RI signaling pathway	KEGG	hsa04664
Pathogenic Escherichia coli infection	KEGG	hsa05130
Prion diseases	KEGG	ko05020
Prion diseases	KEGG	hsa05020
Viral myocarditis	KEGG	hsa05416
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Cholinergic synapse	KEGG	hsa04725
Platelet activation	KEGG	hsa04611
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
Host Interactions of HIV factors	REACTOME	R-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesis	REACTOME	R-HSA-164952
Nef and signal transduction	REACTOME	R-HSA-164944
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Costimulation by the CD28 family	REACTOME	R-HSA-388841
CD28 co-stimulation	REACTOME	R-HSA-389356
CD28 dependent PI3K/Akt signaling	REACTOME	R-HSA-389357
CD28 dependent Vav1 pathway	REACTOME	R-HSA-389359
CTLA4 inhibitory signaling	REACTOME	R-HSA-389513
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME	R-HSA-983695
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME	R-HSA-2029480
FCGR activation	REACTOME	R-HSA-2029481
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
Dectin-2 family	REACTOME	R-HSA-5621480
CD209 (DC-SIGN) signaling	REACTOME	R-HSA-5621575
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Regulation of signaling by CBL	REACTOME	R-HSA-912631
Hemostasis	REACTOME	R-HSA-109582
Platelet Adhesion to exposed collagen	REACTOME	R-HSA-75892
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GPVI-mediated activation cascade	REACTOME	R-HSA-114604
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
PECAM1 interactions	REACTOME	R-HSA-210990
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Regulation of KIT signaling	REACTOME	R-HSA-1433559
Signaling by ERBB2	REACTOME	R-HSA-1227986
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Lipid digestion, mobilization, and transport	REACTOME	R-HSA-73923
Lipoprotein metabolism	REACTOME	R-HSA-174824
Cell-Cell communication	REACTOME	R-HSA-1500931
Nephrin interactions	REACTOME	R-HSA-373753
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME	R-HSA-399955
Sema3A PAK dependent Axon repulsion	REACTOME	R-HSA-399954
CRMPs in Sema3A signaling	REACTOME	R-HSA-399956
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
Netrin-1 signaling	REACTOME	R-HSA-373752
DCC mediated attractive signaling	REACTOME	R-HSA-418885
Netrin mediated repulsion signals	REACTOME	R-HSA-418886
EPH-Ephrin signaling	REACTOME	R-HSA-2682334
EPHA-mediated growth cone collapse	REACTOME	R-HSA-3928663
EPHB-mediated forward signaling	REACTOME	R-HSA-3928662
Ephrin signaling	REACTOME	R-HSA-3928664
EPH-ephrin mediated repulsion of cells	REACTOME	R-HSA-3928665
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
VLDL interactions	REACTOME	R-HSA-8855121
Reelin signalling pathway	REACTOME	R-HSA-8866376
RET signaling	REACTOME	R-HSA-8853659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38714727	2024	YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway.	0
38714727	2024	YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway.	0
35652400	2023	The Interrelationship Between FYN and miR-128/193a-5p/494 in Imatinib Resistance in Prostate Cancer.	2
36563468	2023	Highly expressed FYN promotes the progression of placenta accreta by activating STAT3, p38, and JNK signaling pathways.	0
36740671	2023	FYN: emerging biological roles and potential therapeutic targets in cancer.	9
36754870	2023	Role of Fyn in hematological malignancies.	1
37093456	2023	Advances in the expression and function of Fyn in different human tumors.	0
37958964	2023	Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.	1
35652400	2023	The Interrelationship Between FYN and miR-128/193a-5p/494 in Imatinib Resistance in Prostate Cancer.	2
36563468	2023	Highly expressed FYN promotes the progression of placenta accreta by activating STAT3, p38, and JNK signaling pathways.	0
36740671	2023	FYN: emerging biological roles and potential therapeutic targets in cancer.	9
36754870	2023	Role of Fyn in hematological malignancies.	1
37093456	2023	Advances in the expression and function of Fyn in different human tumors.	0
37958964	2023	Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.	1
35238864	2022	Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling.	8

Citation

Dessen P

FYN (FYN proto-oncogene, Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40653/fyn

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