FZD8 (frizzled class receptor 8)

2003-06-01 Affiliation

Identity

HGNC

FZD8

LOCATION

10p11.21

LOCUSID

8325

ALIAS

FZ-8,hFZ8

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8325
MIM: 606146
HGNC: 4046
Ensembl: ENSG00000177283

Variants:

dbSNP: 8325
ClinVar: 8325
TCGA: ENSG00000177283
COSMIC: FZD8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000177283	ENST00000374694	Q9H461

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
Wnt signaling pathway	KEGG	ko04310
Melanogenesis	KEGG	ko04916
Basal cell carcinoma	KEGG	ko05217
mTOR signaling pathway	KEGG	hsa04150
Wnt signaling pathway	KEGG	hsa04310
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Basal cell carcinoma	KEGG	hsa05217
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Wnt signaling	KEGG	hsa_M00677
Wnt signaling	KEGG	M00677
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by WNT in cancer	REACTOME	R-HSA-4791275
RNF mutants show enhanced WNT signaling and proliferation	REACTOME	R-HSA-5340588
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Regulation of FZD by ubiquitination	REACTOME	R-HSA-4641263
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
Asymmetric localization of PCP proteins	REACTOME	R-HSA-4608870
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20093360	2010	Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.	69
26590425	2015	K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.	63
25702574	2015	Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.	47
25320014	2014	Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas.	31
26537584	2016	MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway.	25
20634891	2010	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	18
27276676	2016	MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8.	16
28602974	2017	FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling.	14
29717114	2018	Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.	14
23815780	2013	Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer.	12

Citation

Dessen P

FZD8 (frizzled class receptor 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40658/fzd8