FZR1 (fizzy and cell division cycle 20 related 1)

2007-04-01  

Identity

HGNC
FZR1
LOCATION
19p13.3
LOCUSID
51343
ALIAS
CDC20C,CDH1,FZR,FZR2,HCDH,HCDH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51343
MIM: 603619
HGNC: 24824
Ensembl: ENSG00000105325

Variants:

dbSNP: 51343
ClinVar: 51343
TCGA: ENSG00000105325
COSMIC: FZR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105325ENST00000313639Q9UM11
ENSG00000105325ENST00000395095Q9UM11
ENSG00000105325ENST00000441788Q9UM11
ENSG00000105325ENST00000591290K7EQT1
ENSG00000105325ENST00000652521Q9UM11

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
Progesterone-mediated oocyte maturationKEGGhsa04914
APC/C complexKEGGhsa_M00389
APC/C complexKEGGM00389
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
Regulation of DNA replicationREACTOMER-HSA-69304
Removal of licensing factors from originsREACTOMER-HSA-69300
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Phosphorylation of Emi1REACTOMER-HSA-176417
SCF-beta-TrCP mediated degradation of Emi1REACTOMER-HSA-174113
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/CREACTOMER-HSA-174084
DNA ReplicationREACTOMER-HSA-69306
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
186625412008The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.180
212418902011Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.162
215963152011Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.66
200807442010E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation.65
211863642011Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.58
189769102008APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase.57
273681032016Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.53
209214112010Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.50
183219832008APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle.48
150292442004Mammalian Cdh1/Fzr mediates its own degradation.47

Citation

Dessen P

FZR1 (fizzy and cell division cycle 20 related 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47270/fzr1