G3BP2 (G3BP stress granule assembly factor 2)

2007-08-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 9908
HGNC: 30291
Ensembl: ENSG00000138757

Variants:

dbSNP: 9908
ClinVar: 9908
TCGA: ENSG00000138757
COSMIC: G3BP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138757ENST00000357854Q9UN86
ENSG00000138757ENST00000357854A0A024RDB2
ENSG00000138757ENST00000359707Q9UN86
ENSG00000138757ENST00000359707A0A024RDE5
ENSG00000138757ENST00000395719Q9UN86
ENSG00000138757ENST00000395719A0A024RDE5
ENSG00000138757ENST00000499709D6R9X5
ENSG00000138757ENST00000503660D6RB17
ENSG00000138757ENST00000507252D6RBR0
ENSG00000138757ENST00000507745D6RAC7
ENSG00000138757ENST00000508510D6R9A4
ENSG00000138757ENST00000509100D6RGJ4
ENSG00000138757ENST00000509561D6RBM9
ENSG00000138757ENST00000510902H0YAE3
ENSG00000138757ENST00000511146D6RBW8
ENSG00000138757ENST00000511868D6REX8
ENSG00000138757ENST00000515457D6RE13

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258939172015Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.187
270220922016G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.114
249920362014G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.96
230872122012Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection.77
232792042013Both G3BP1 and G3BP2 contribute to stress granule formation.68
256534512015Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.48
172974772007Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP).29
225364442012PKCα binds G3BP2 and regulates stress granule formation following cellular stress.16
286920472017Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer.13
293791642018TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer.13

Citation

Dessen P

G3BP2 (G3BP stress granule assembly factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47700/g3bp2