G6PC2 (glucose-6-phosphatase catalytic subunit 2)

2014-11-01 Affiliation

Identity

HGNC

G6PC2

LOCATION

2q31.1

LOCUSID

57818

ALIAS

IGRP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57818
MIM: 608058
HGNC: 28906
Ensembl: ENSG00000152254

Variants:

dbSNP: 57818
ClinVar: 57818
TCGA: ENSG00000152254
COSMIC: G6PC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000152254	ENST00000282075	Q9NQR9
ENSG00000152254	ENST00000375363	Q9NQR9
ENSG00000152254	ENST00000421979	C9IYU7
ENSG00000152254	ENST00000429379	Q9NQR9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycolysis / Gluconeogenesis	KEGG	ko00010
Galactose metabolism	KEGG	ko00052
Starch and sucrose metabolism	KEGG	ko00500
Insulin signaling pathway	KEGG	ko04910
Adipocytokine signaling pathway	KEGG	ko04920
Glycolysis / Gluconeogenesis	KEGG	hsa00010
Galactose metabolism	KEGG	hsa00052
Starch and sucrose metabolism	KEGG	hsa00500
Insulin signaling pathway	KEGG	hsa04910
Adipocytokine signaling pathway	KEGG	hsa04920
Metabolic pathways	KEGG	hsa01100
Carbohydrate digestion and absorption	KEGG	ko04973
Carbohydrate digestion and absorption	KEGG	hsa04973
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
FoxO signaling pathway	KEGG	hsa04068
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Insulin resistance	KEGG	hsa04931

References

Pubmed ID	Year	Title	Citations
19060907	2009	Variants in MTNR1B influence fasting glucose levels.	298
20858683	2010	Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.	170
18451265	2008	A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.	110
18451265	2008	A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.	110
18521185	2008	Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.	79
18521185	2008	Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.	79
19096518	2008	Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.	48
19651812	2009	Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.	46
25625282	2015	Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.	42
16493034	2006	Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.	40

Citation

Dessen P

G6PC2 (glucose-6-phosphatase catalytic subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63639/g6pc2