GABARAP (GABA type A receptor-associated protein)

2007-02-01  

Identity

HGNC
GABARAP
LOCATION
17p13.1
LOCUSID
11337
ALIAS
ATG8A,GABARAP-a,MM46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11337
MIM: 605125
HGNC: 4067
Ensembl: ENSG00000170296

Variants:

dbSNP: 11337
ClinVar: 11337
TCGA: ENSG00000170296
COSMIC: GABARAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170296ENST00000302386O95166
ENSG00000170296ENST00000302386Q6IAW1
ENSG00000170296ENST00000570856I3L3J4
ENSG00000170296ENST00000571129I3L236
ENSG00000170296ENST00000571253I3L236
ENSG00000170296ENST00000573928H6UMI1
ENSG00000170296ENST00000577035I3L236

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
FoxO signaling pathwayKEGGhsa04068
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
TBC/RABGAPsREACTOMER-HSA-8854214
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

References

Pubmed IDYearTitleCitations
254981452015PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.135
278643212016Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.125
118259102002Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.79
193633022009Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy.78
163037672006Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.67
266875992015Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130.42
256842052015CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.31
175819662007Sustained structural change of GABA(A) receptor-associated protein underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron.30
163390172005Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein.28
251267262014FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.28

Citation

Dessen P

GABARAP (GABA type A receptor-associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43973/gabarap