GABPA (GA binding protein transcription factor subunit alpha)

2007-02-01  

Identity

HGNC
GABPA
LOCATION
21q21.3
LOCUSID
2551
ALIAS
E4TF1-60,E4TF1A,NFT2,NRF2,NRF2A,RCH04A07
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2551
MIM: 600609
HGNC: 4071
Ensembl: ENSG00000154727

Variants:

dbSNP: 2551
ClinVar: 2551
TCGA: ENSG00000154727
COSMIC: GABPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154727ENST00000354828Q06546
ENSG00000154727ENST00000354828A8IE48
ENSG00000154727ENST00000400075Q06546
ENSG00000154727ENST00000400075A8IE48

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
259773702015Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.148
196871462009Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery.68
153618672004GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells.53
276509512016Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation.43
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
199519462010Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication.24
173042212007Postsynaptic chromatin is under neural control at the neuromuscular junction.22
180207122007The ets-related transcription factor GABP directs bidirectional transcription.22
216245092011Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity.19
232846282012The ETS transcription factors ELK1 and GABPA regulate different gene networks to control MCF10A breast epithelial cell migration.17

Citation

Dessen P

GABPA (GA binding protein transcription factor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45863/gabpa