GABRP (gamma-aminobutyric acid type A receptor subunit pi)

2003-08-01  

Identity

HGNC
LOCATION
5q35.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 2568
MIM: 602729
HGNC: 4089
Ensembl: ENSG00000094755

Variants:

dbSNP: 2568
ClinVar: 2568
TCGA: ENSG00000094755
COSMIC: GABRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000094755ENST00000265294O00591
ENSG00000094755ENST00000518122E5RHF6
ENSG00000094755ENST00000518525O00591
ENSG00000094755ENST00000519196E5RHU0
ENSG00000094755ENST00000519385E7EWG0
ENSG00000094755ENST00000519598E5RI57
ENSG00000094755ENST00000521009E5RK74
ENSG00000094755ENST00000521481E5RG98
ENSG00000094755ENST00000522868E5RGF7

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713257Selective serotonin reuptake inhibitorsChemicalClinicalAnnotationassociatedPD23394390
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD23394390
PA451866venlafaxineChemicalClinicalAnnotationassociatedPD23394390
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD23394390

References

Pubmed IDYearTitleCitations
373268972024GABRP Promotes the Metastasis of Pancreatic Cancer by Activation of the MEK/ERK Signaling Pathway.1
373268972024GABRP Promotes the Metastasis of Pancreatic Cancer by Activation of the MEK/ERK Signaling Pathway.1
358468842022GABRP promotes CD44s-mediated gemcitabine resistance in pancreatic cancer.2
358468842022GABRP promotes CD44s-mediated gemcitabine resistance in pancreatic cancer.2
340234182021GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling.11
347900612021The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers.2
340234182021GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling.11
347900612021The Emerging Roles of π Subunit-Containing GABA(A) Receptors in Different Cancers.2
323591612020Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast.22
323591612020Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast.22
291350682018Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.1
291350682018Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.1
285241802017Aberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer.27
285241802017Aberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer.27
266342172015The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus.3

Citation

Dessen P

GABRP (gamma-aminobutyric acid type A receptor subunit pi)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40665/gabrp