GADD45B (growth arrest and DNA damage inducible beta)

2003-08-01  

Identity

HGNC
GADD45B
LOCATION
19p13.3
LOCUSID
4616
ALIAS
GADD45BETA,MYD118

Other Information

Locus ID:

NCBI: 4616
MIM: 604948
HGNC: 4096
Ensembl: ENSG00000099860

Variants:

dbSNP: 4616
ClinVar: 4616
TCGA: ENSG00000099860
COSMIC: GADD45B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099860ENST00000215631O75293
ENSG00000099860ENST00000585359K7EM97
ENSG00000099860ENST00000587345K7EPQ8
ENSG00000099860ENST00000587887Q6IX74
ENSG00000099860ENST00000593043Q6IX74

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
MAPK signaling pathwayKEGGhsa04010
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
FoxO signaling pathwayKEGGhsa04068

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185763892008Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.43
218109432011Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors.43
220484582012Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis.43
161448442005A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation.39
210629762010Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells.32
174854672007Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2.31
127592522003Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma.28
128555712003Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis.24
156427342005Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation.24
211270532011Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.24

Citation

Dessen P

GADD45B (growth arrest and DNA damage inducible beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40666/gadd45b