GALNT14 (polypeptide N-acetylgalactosaminyltransferase 14)

2010-06-01  

Identity

HGNC
GALNT14
LOCATION
2p23.1
LOCUSID
79623
ALIAS
GALNT15,GalNac-T10,GalNac-T14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79623
MIM: 608225
HGNC: 22946
Ensembl: ENSG00000158089

Variants:

dbSNP: 79623
ClinVar: 79623
TCGA: ENSG00000158089
COSMIC: GALNT14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158089ENST00000324589Q96FL9
ENSG00000158089ENST00000349752Q96FL9
ENSG00000158089ENST00000406653Q96FL9
ENSG00000158089ENST00000424136H7C168
ENSG00000158089ENST00000430167J3KQQ5
ENSG00000158089ENST00000455477H7C1E3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mucin type O-glycan biosynthesisKEGGko00512
Mucin type O-glycan biosynthesisKEGGhsa00512
Metabolic pathwaysKEGGhsa01100
O-glycan biosynthesis, mucin type coreKEGGhsa_M00056
O-glycan biosynthesis, mucin type coreKEGGM00056
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD21635146, 31611591
PA444445Hepatitis CDiseaseClinicalAnnotationassociatedPD31611591
PA444447Carcinoma, HepatocellularDiseaseClinicalAnnotationassociatedPD21635146, 31611591
PA444804Liver NeoplasmsDiseaseClinicalAnnotationassociatedPD31611591
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21635146, 31611591
PA449014cisplatinChemicalClinicalAnnotationassociatedPD21635146, 31611591
PA450526mitoxantroneChemicalClinicalAnnotationassociatedPD21635146, 31611591
PA7000sorafenibChemicalClinicalAnnotationassociatedPD31611591

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
125075122003Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14.24
203564182010N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry.24
249629472015GALNT14 mediates tumor invasion and migration in breast cancer cell MCF-7.21
201792152010Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab.14
239599472014A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma.13
263091602015Identification of GALNT14 as a novel neuroblastoma predisposition gene.13
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
265448962015GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma.9
268716392016GALNT14 genotype effectively predicts the therapeutic response in unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization.7

Citation

Dessen P

GALNT14 (polypeptide N-acetylgalactosaminyltransferase 14)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51524/galnt14