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GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6)

Identity

Alias (NCBI)GALNACT20
GALNT17
GalNAc-T6L
HGNC (Hugo) GALNTL6
HGNC Alias symbGALNT17
GalNAc-T6L
HGNC Alias namepolypeptide GalNAc transferase-like 6
HGNC Previous nameUDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
LocusID (NCBI) 442117
Atlas_Id 63692
Location 4q34.1  [Link to chromosome band 4q34]
Location_base_pair Starts at 171813424 and ends at 173040407 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CBR4 (4q32.3) / GALNTL6 (4q34.1)DNAJA1 (9p21.1) / GALNTL6 (4q34.1)RASAL2 (1q25.2) / GALNTL6 (4q34.1)
VEGFC (4q34.3) / GALNTL6 (4q34.1)DNAJA1 GALNTL6RASAL2 GALNTL6
CBR4 GALNTL6

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(1;4)(q25;q34) RASAL2/GALNTL6
t(4;4)(q32;q34) CBR4/GALNTL6
t(4;9)(q34;p21) DNAJA1/GALNTL6

External links

Nomenclature
HGNC (Hugo)GALNTL6   33844
Cards
Entrez_Gene (NCBI)GALNTL6  442117  polypeptide N-acetylgalactosaminyltransferase like 6
AliasesGALNACT20; GALNT17; GalNAc-T6L
GeneCards (Weizmann)GALNTL6
Ensembl hg19 (Hinxton)ENSG00000174473 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174473 [Gene_View]  ENSG00000174473 [Sequence]  chr4:171813424-173040407 [Contig_View]  GALNTL6 [Vega]
ICGC DataPortalENSG00000174473
TCGA cBioPortalGALNTL6
AceView (NCBI)GALNTL6
Genatlas (Paris)GALNTL6
WikiGenes442117
SOURCE (Princeton)GALNTL6
Genetics Home Reference (NIH)GALNTL6
Genomic and cartography
GoldenPath hg38 (UCSC)GALNTL6  -     chr4:171813424-173040407 +  4q34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GALNTL6  -     4q34.1   [Description]    (hg19-Feb_2009)
GoldenPathGALNTL6 - 4q34.1 [CytoView hg19]  GALNTL6 - 4q34.1 [CytoView hg38]
ImmunoBaseENSG00000174473
genome Data Viewer NCBIGALNTL6 [Mapview hg19]  
OMIM615138   
Gene and transcription
Genbank (Entrez)AJ626725 AK124240 AK295464 BC044793 BC047551
RefSeq transcript (Entrez)NM_001034845
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GALNTL6
Alternative Splicing GalleryENSG00000174473
Gene ExpressionGALNTL6 [ NCBI-GEO ]   GALNTL6 [ EBI - ARRAY_EXPRESS ]   GALNTL6 [ SEEK ]   GALNTL6 [ MEM ]
Gene Expression Viewer (FireBrowse)GALNTL6 [ Firebrowse - Broad ]
GenevisibleExpression of GALNTL6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)442117
GTEX Portal (Tissue expression)GALNTL6
Human Protein AtlasENSG00000174473-GALNTL6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ49A17   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ49A17  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ49A17
Splice isoforms : SwissVarQ49A17
Catalytic activity : Enzyme2.4.1.41 [ Enzyme-Expasy ]   2.4.1.412.4.1.41 [ IntEnz-EBI ]   2.4.1.41 [ BRENDA ]   2.4.1.41 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ49A17
Domaine pattern : Prosite (Expaxy)RICIN_B_LECTIN (PS50231)   
Domains : Interpro (EBI)Glyco_trans_2-like    Nucleotide-diphossugar_trans    Ricin_B-like_lectins    Ricin_B_lectin   
Domain families : Pfam (Sanger)Glycos_transf_2 (PF00535)    Ricin_B_lectin (PF00652)   
Domain families : Pfam (NCBI)pfam00535    pfam00652   
Domain families : Smart (EMBL)RICIN (SM00458)  
Conserved Domain (NCBI)GALNTL6
DMDM Disease mutations442117
Blocks (Seattle)GALNTL6
SuperfamilyQ49A17
Human Protein Atlas [tissue]ENSG00000174473-GALNTL6 [tissue]
Peptide AtlasQ49A17
IPIIPI00454894   IPI00888755   IPI00910400   IPI00964878   
Protein Interaction databases
DIP (DOE-UCLA)Q49A17
IntAct (EBI)Q49A17
FunCoupENSG00000174473
BioGRIDGALNTL6
STRING (EMBL)GALNTL6
ZODIACGALNTL6
Ontologies - Pathways
QuickGOQ49A17
Ontology : AmiGOGolgi membrane  polypeptide N-acetylgalactosaminyltransferase activity  Golgi apparatus  integral component of membrane  protein O-linked glycosylation via threonine  carbohydrate binding  metal ion binding  
Ontology : EGO-EBIGolgi membrane  polypeptide N-acetylgalactosaminyltransferase activity  Golgi apparatus  integral component of membrane  protein O-linked glycosylation via threonine  carbohydrate binding  metal ion binding  
Pathways : KEGGGlycan structures - biosynthesis 1    O-Glycan biosynthesis   
NDEx NetworkGALNTL6
Atlas of Cancer Signalling NetworkGALNTL6
Wikipedia pathwaysGALNTL6
Orthology - Evolution
OrthoDB442117
GeneTree (enSembl)ENSG00000174473
Phylogenetic Trees/Animal Genes : TreeFamGALNTL6
HOGENOMQ49A17
Homologs : HomoloGeneGALNTL6
Homology/Alignments : Family Browser (UCSC)GALNTL6
Gene fusions - Rearrangements
Fusion PortalDNAJA1 GALNTL6
Fusion PortalRASAL2 GALNTL6
Fusion PortalCBR4 GALNTL6
Fusion : QuiverGALNTL6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGALNTL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GALNTL6
dbVarGALNTL6
ClinVarGALNTL6
1000_GenomesGALNTL6 
Exome Variant ServerGALNTL6
GNOMAD BrowserENSG00000174473
Varsome BrowserGALNTL6
Genetic variants : HAPMAP442117
Genomic Variants (DGV)GALNTL6 [DGVbeta]
DECIPHERGALNTL6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGALNTL6 
Mutations
ICGC Data PortalGALNTL6 
TCGA Data PortalGALNTL6 
Broad Tumor PortalGALNTL6
OASIS PortalGALNTL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGALNTL6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGALNTL6
Mutations and Diseases : HGMDGALNTL6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GALNTL6
DgiDB (Drug Gene Interaction Database)GALNTL6
DoCM (Curated mutations)GALNTL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GALNTL6 (select a term)
intoGenGALNTL6
Cancer3DGALNTL6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615138   
Orphanet
DisGeNETGALNTL6
MedgenGALNTL6
Genetic Testing Registry GALNTL6
NextProtQ49A17 [Medical]
TSGene442117
GENETestsGALNTL6
Target ValidationGALNTL6
Huge Navigator GALNTL6 [HugePedia]
snp3D : Map Gene to Disease442117
BioCentury BCIQGALNTL6
ClinGenGALNTL6
Clinical trials, drugs, therapy
Protein Interactions : CTD442117
Pharm GKB GenePA164720162
Clinical trialGALNTL6
Miscellaneous
canSAR (ICR)GALNTL6 (select the gene name)
HarmonizomeGALNTL6
DataMed IndexGALNTL6
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGALNTL6
EVEXGALNTL6
GoPubMedGALNTL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Aug 22 19:12:25 CEST 2020
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