GALR1 (galanin receptor 1)

2009-03-01 Affiliation

Identity

HGNC

GALR1

LOCATION

18q23

LOCUSID

2587

ALIAS

GALNR,GALNR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2587
MIM: 600377
HGNC: 4132
Ensembl: ENSG00000166573

Variants:

dbSNP: 2587
ClinVar: 2587
TCGA: ENSG00000166573
COSMIC: GALR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166573	ENST00000299727	P47211

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA445876	Tobacco Use Disorder	Disease	ClinicalAnnotation	associated	PD	21430647, 22373943
PA448687	bupropion	Chemical	ClinicalAnnotation	associated	PD
PA450626	nicotine	Chemical	ClinicalAnnotation	associated	PD	21430647, 22373943

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
20398908	2010	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	32
20171159	2010	Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization.	30
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
24706871	2014	Brain galanin system genes interact with life stresses in depression-related phenotypes.	28
19047085	2008	Epigenetic inactivation of galanin receptor 1 in head and neck cancer.	25
17083333	2007	Alcoholism is associated with GALR3 but not two other galanin receptor genes.	24
17083333	2007	Alcoholism is associated with GALR3 but not two other galanin receptor genes.	24

Citation

Dessen P

GALR1 (galanin receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50690/galr1