GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)

2014-11-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
ARF1GEF
FUSION GENES

Other Information

Locus ID:

NCBI: 8729
MIM: 603698
HGNC: 4181
Ensembl: ENSG00000107862

Variants:

dbSNP: 8729
ClinVar: 8729
TCGA: ENSG00000107862
COSMIC: GBF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107862ENST00000369983Q92538

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156161902005Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi.101
170793302007Hijacking components of the cellular secretory pathway for replication of poliovirus RNA.99
197409862009GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication.94
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
190234172008A critical role of a cellular membrane traffic protein in poliovirus RNA replication.83
219092602011Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development.83
185511692008Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation.72
199069302010Identification of GBF1 as a cellular factor required for hepatitis C virus RNA replication.72
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
120475562002GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat.62

Citation

Dessen P

GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63723/gbf1