GBP2 (guanylate binding protein 2)

2003-06-01  

Identity

HGNC
LOCATION
1p22.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 2634
MIM: 600412
HGNC: 4183
Ensembl: ENSG00000162645

Variants:

dbSNP: 2634
ClinVar: 2634
TCGA: ENSG00000162645
COSMIC: GBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162645ENST00000370466P32456
ENSG00000162645ENST00000464839P32456

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230864062013Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins.49
211518712010Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.35
228643582013miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
230015062014Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response.24
124478672002Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.12
290726872017Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.11
190039642009Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas.9
175178952007Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions.8
310914482019Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.8

Citation

Dessen P

GBP2 (guanylate binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40692/gbp2