GBP5 (guanylate binding protein 5)

2007-02-01  

Identity

HGNC
GBP5
LOCATION
1p22.2
LOCUSID
115362
ALIAS
GBP-5

Other Information

Locus ID:

NCBI: 115362
MIM: 611467
HGNC: 19895
Ensembl: ENSG00000154451

Variants:

dbSNP: 115362
ClinVar: 115362
TCGA: ENSG00000154451
COSMIC: GBP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154451ENST00000370459Q96PP8
ENSG00000154451ENST00000443807E7ETN8

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224615012012GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.146
269963072016Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity.56
211518712010Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.35
172664432007Unique features of different members of the human guanylate-binding protein family.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
260255972015A real-time PCR signature to discriminate between tuberculosis and other pulmonary diseases.12
201808472010Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant.11
283765012017Inducible GBP5 Mediates the Antiviral Response via Interferon-Related Pathways during Influenza A Virus Infection.11
151750442004GBP-5 splicing variants: New guanylate-binding proteins with tumor-associated expression and antigenicity.8
310914482019Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.8

Citation

Dessen P

GBP5 (guanylate binding protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46108/gbp5