GCA (grancalcin)

2016-10-01  

Identity

HGNC
LOCATION
2q24.2
LOCUSID
ALIAS
GCL
FUSION GENES

Other Information

Locus ID:

NCBI: 25801
MIM: 607030
HGNC: 15990
Ensembl: ENSG00000115271

Variants:

dbSNP: 25801
ClinVar: 25801
TCGA: ENSG00000115271
COSMIC: GCA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115271ENST00000233612H7BXD5
ENSG00000115271ENST00000414723H7C2Z6
ENSG00000115271ENST00000429691C9JV47
ENSG00000115271ENST00000437150P28676
ENSG00000115271ENST00000446271C9JWQ8
ENSG00000115271ENST00000453113C9JIZ3

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
182858332008IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.19
182858332008IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.19
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
180716702008The association between the IFIH1 locus and type 1 diabetes.10
128047662003The PEF family proteins sorcin and grancalcin interact in vivo and in vitro.4
191561662009IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.2
191561662009IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.2
266484802016Grancalcin (GCA) modulates Toll-like receptor 9 (TLR9) mediated signaling through its direct interaction with TLR9.2

Citation

Dessen P

GCA (grancalcin)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56282/gca