GCC2 (GRIP and coiled-coil domain containing 2)

2012-11-01  

Identity

HGNC
GCC2
LOCATION
2q12.3
LOCUSID
9648
ALIAS
GCC185,RANBP2L4,REN53
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9648
MIM: 612711
HGNC: 23218
Ensembl: ENSG00000135968

Variants:

dbSNP: 9648
ClinVar: 9648
TCGA: ENSG00000135968
COSMIC: GCC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135968ENST00000309863Q8IWJ2
ENSG00000135968ENST00000393321H7BYJ9
ENSG00000135968ENST00000409821B8ZZA5
ENSG00000135968ENST00000409896B8ZZW2
ENSG00000135968ENST00000447558H7C010
ENSG00000135968ENST00000462897U3KPU4
ENSG00000135968ENST00000482325Q8IWJ2
ENSG00000135968ENST00000492785U3KQE0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
318401802020Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.22
318401802020Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.22
271059132016HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.1
271059132016HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.1
266538562015Protein flexibility is required for vesicle tethering at the Golgi.38
266538562015Protein flexibility is required for vesicle tethering at the Golgi.38
218759482011GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering.24
221594192011ARL4A acts with GCC185 to modulate Golgi complex organization.20
218759482011GCC185 plays independent roles in Golgi structure maintenance and AP-1-mediated vesicle tethering.24
221594192011ARL4A acts with GCC185 to modulate Golgi complex organization.20
189460812009Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.49
197034032009The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.19
189460812009Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.49
197034032009The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.19
182431032008Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.88

Citation

Dessen P

GCC2 (GRIP and coiled-coil domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53005/gcc2