Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2646
MIM: 600842
HGNC: 4196
Ensembl: ENSG00000084734
Variants:
dbSNP: 2646
ClinVar: 2646
TCGA: ENSG00000084734
COSMIC: GCKR
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000084734 | ENST00000264717 | A0A0C4DFN2 |
| ENSG00000084734 | ENST00000411584 | H7C4D3 |
| ENSG00000084734 | ENST00000417872 | Q14397 |
| ENSG00000084734 | ENST00000453813 | H7C1B4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | 32451486 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | 32451486 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38101397 | 2024 | ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits. | 2 |
| 38101397 | 2024 | ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits. | 2 |
| 37081070 | 2023 | Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD. | 4 |
| 37524927 | 2023 | GCKR and ADIPOQ gene polymorphisms in women with gestational diabetes mellitus. | 1 |
| 37648893 | 2023 | Interaction between the GCKR rs1260326 variant and serum HDL cholesterol contributes to HOMA-β and ISI(Matusda) in the middle-aged T2D individuals. | 1 |
| 37829557 | 2023 | Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan. | 1 |
| 37081070 | 2023 | Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD. | 4 |
| 37524927 | 2023 | GCKR and ADIPOQ gene polymorphisms in women with gestational diabetes mellitus. | 1 |
| 37648893 | 2023 | Interaction between the GCKR rs1260326 variant and serum HDL cholesterol contributes to HOMA-β and ISI(Matusda) in the middle-aged T2D individuals. | 1 |
| 37829557 | 2023 | Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan. | 1 |
| 35276241 | 2022 | Association of glucokinase gene and glucokinase regulatory protein gene polymorphisms with gestational diabetes mellitus: A case-control study. | 6 |
| 35328045 | 2022 | Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits. | 10 |
| 35657990 | 2022 | Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes. | 2 |
| 36243233 | 2022 | GCKR and GCK polymorphisms are associated with increased risk of end-stage kidney disease in Chinese patients with type 2 diabetes: The Hong Kong Diabetes Register (1995-2019). | 4 |
| 35276241 | 2022 | Association of glucokinase gene and glucokinase regulatory protein gene polymorphisms with gestational diabetes mellitus: A case-control study. | 6 |
Citation
Dessen P
GCKR (glucokinase regulator)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50240/gckr
