GCNT1 (glucosaminyl (N-acetyl) transferase 1)

2007-02-01  

Identity

HGNC
LOCATION
9q21.13
LOCUSID
ALIAS
C2GNT,C2GNT-L,C2GNT1,G6NT,NACGT2,NAGCT2
FUSION GENES

Other Information

Locus ID:

NCBI: 2650
MIM: 600391
HGNC: 4203
Ensembl: ENSG00000187210

Variants:

dbSNP: 2650
ClinVar: 2650
TCGA: ENSG00000187210
COSMIC: GCNT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187210ENST00000376730Q02742
ENSG00000187210ENST00000442371Q02742
ENSG00000187210ENST00000444201Q02742

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Mucin type O-glycan biosynthesisKEGGko00512
Mucin type O-glycan biosynthesisKEGGhsa00512
Metabolic pathwaysKEGGhsa01100
O-glycan biosynthesis, mucin type coreKEGGhsa_M00056
O-glycan biosynthesis, mucin type coreKEGGM00056
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217128122011A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans.45
230278622012Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1.32
159329192005Expression of core 2 beta1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progression.23
250860692014Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis.23
179476422007Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I.18
167781382006Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death.16
231659402013Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity.15
239904502014Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases.15
248546302014Increased expression of GCNT1 is associated with altered O-glycosylation of PSA, PAP, and MUC1 in human prostate cancers.15
200171382010Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor.13

Citation

Dessen P

GCNT1 (glucosaminyl (N-acetyl) transferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43762/gcnt1