GDE1 (glycerophosphodiester phosphodiesterase 1)

2010-10-01  

Identity

HGNC
LOCATION
16p12.3
LOCUSID
ALIAS
363E6.2,MIR16
FUSION GENES

Other Information

Locus ID:

NCBI: 51573
MIM: 605943
HGNC: 29644
Ensembl: ENSG00000006007

Variants:

dbSNP: 51573
ClinVar: 51573
TCGA: ENSG00000006007
COSMIC: GDE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006007ENST00000353258Q9NZC3
ENSG00000006007ENST00000564172H3BU22
ENSG00000006007ENST00000569773H3BNA5
ENSG00000006007ENST00000569899H3BRL5

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Glycerophospholipid catabolismREACTOMER-HSA-6814848

References

Pubmed IDYearTitleCitations
234052352013Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer.70
182270592008Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.68
210814692011NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors.64
206680642010Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.58
257432732015Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma.41
260334532015Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients.33
243360732013miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress.31
200312112010Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma.26
125765452003GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors.23
271576132016MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.23

Citation

Dessen P

GDE1 (glycerophosphodiester phosphodiesterase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51727/gde1