GDF11 (growth differentiation factor 11)

2007-04-01  

Identity

HGNC
GDF11
LOCATION
12q13.2
LOCUSID
10220
ALIAS
BMP-11,BMP11,VHO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10220
MIM: 603936
HGNC: 4216
Ensembl: ENSG00000135414

Variants:

dbSNP: 10220
ClinVar: 10220
TCGA: ENSG00000135414
COSMIC: GDF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135414ENST00000257868O95390
ENSG00000135414ENST00000257868A0A024RB20
ENSG00000135414ENST00000546799H0YI30

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
260014232015GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.169
246580772014An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.78
263839702015GDF11 does not rescue aging-related pathological hypertrophy.67
273045122016Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease.60
270342752016Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.53
185351062008Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin.45
185196392008VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.42
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
185960302008Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.25
282576342017Structural basis for potency differences between GDF8 and GDF11.22

Citation

Dessen P

GDF11 (growth differentiation factor 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47379/gdf11