GDF2 (growth differentiation factor 2)

2007-04-01  

Identity

HGNC
LOCATION
10q11.22
LOCUSID
ALIAS
BMP-9,BMP9,HHT5

Other Information

Locus ID:

NCBI: 2658
MIM: 605120
HGNC: 4217
Ensembl: ENSG00000263761

Variants:

dbSNP: 2658
ClinVar: 2658
TCGA: ENSG00000263761
COSMIC: GDF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000263761ENST00000581492Q9UK05

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170681492007Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.227
173118492007BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis.179
183091012008Bone morphogenetic protein-9 is a circulating vascular quiescence factor.143
158514682005Crystal structure of BMP-9 and functional interactions with pro-region and receptors.105
193666992009Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells.76
217374542011Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.76
189869832009Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.74
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
204068892010BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo.69
217103212012BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain.55

Citation

Dessen P

GDF2 (growth differentiation factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46771/gdf2