GDF7 (growth differentiation factor 7)

2007-04-01  

Identity

HGNC
LOCATION
2p24.1
LOCUSID
ALIAS
BMP12

Other Information

Locus ID:

NCBI: 151449
MIM: 604651
HGNC: 4222
Ensembl: ENSG00000143869

Variants:

dbSNP: 151449
ClinVar: 151449
TCGA: ENSG00000143869
COSMIC: GDF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143869ENST00000272224Q7Z4P5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
Axon guidanceKEGGko04360
TGF-beta signaling pathwayKEGGhsa04350
Axon guidanceKEGGhsa04360
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390

References

Pubmed IDYearTitleCitations
127419872003A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons.86
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
241559672013BMP12 induces tenogenic differentiation of adipose-derived stromal cells.36
254478512015Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.35
203346102010BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
217027182011Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.15
282144722017Bmp-12 activates tenogenic pathway in human adipose stem cells and affects their immunomodulatory and secretory properties.7
267830832016The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.6

Citation

Dessen P

GDF7 (growth differentiation factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46990/gdf7