GET4 (guided entry of tail-anchored proteins factor 4)

2014-11-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
C7orf20,CEE,CGI-20,TRC35
FUSION GENES

Other Information

Locus ID:

NCBI: 51608
MIM: 612056
HGNC: 21690
Ensembl: ENSG00000239857

Variants:

dbSNP: 51608
ClinVar: 51608
TCGA: ENSG00000239857
COSMIC: GET4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239857ENST00000265857Q7L5D6
ENSG00000239857ENST00000407192Q7L5D6
ENSG00000239857ENST00000412734C9JPA8
ENSG00000239857ENST00000426056C9JY46
ENSG00000239857ENST00000441491C9JHN8

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232460012012SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.38
236655632013A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.31
255353732015Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.26
247278352014Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.19
237230672013Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.10

Citation

Dessen P

GET4 (guided entry of tail-anchored proteins factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63753/get4