GFER (growth factor, augmenter of liver regeneration)

2007-02-01  

Identity

HGNC
GFER
LOCATION
16p13.3
LOCUSID
2671
ALIAS
ALR,ERV1,HERV1,HPO,HPO1,HPO2,HSS,MMCHD,MPMCD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2671
MIM: 600924
HGNC: 4236
Ensembl: ENSG00000127554

Variants:

dbSNP: 2671
ClinVar: 2671
TCGA: ENSG00000127554
COSMIC: GFER

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127554ENST00000248114P55789
ENSG00000127554ENST00000561710H3BRD2
ENSG00000127554ENST00000567719H3BQQ4
ENSG00000127554ENST00000569451H3BRW3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
281142692017A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.71
213831382011Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR.41
242259522013Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation.41
194095222009The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.39
236766652013Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.30
289646252017Regulation of the Hippo Pathway Transcription Factor TEAD.30
193973382009Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space.26
238876912013Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration.25
173363032007The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway.24
182722482008Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes.23

Citation

Dessen P

GFER (growth factor, augmenter of liver regeneration)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46576/gfer