Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GFM1 (G elongation factor mitochondrial 1)

Identity

Alias_namesG translation elongation factor, mitochondrial
Alias_symbol (synonym)EFGM
GFM
EGF1
mtEF-G1
Other aliasCOXPD1
EFG
EFG1
hEFG1
HGNC (Hugo) GFM1
LocusID (NCBI) 85476
Atlas_Id 56719
Location 3q25.32  [Link to chromosome band 3q25]
Location_base_pair Starts at 158644528 and ends at 158692571 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GFM1 (3q25.32) / GFM1 (3q25.32)GFM1 (3q25.32) / MLF1 (3q25.32)GFM1 (3q25.32) / SMARCA2 (9p24.3)
MFSD1 (3q25.32) / GFM1 (3q25.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  GFM1/MLF1 (3q25)
GFM1/RARRES1 (3q25)
MFSD1/GFM1 (3q25)

External links

Nomenclature
HGNC (Hugo)GFM1   13780
Cards
Entrez_Gene (NCBI)GFM1  85476  G elongation factor mitochondrial 1
AliasesCOXPD1; EFG; EFG1; EFGM; 
EGF1; GFM; hEFG1; mtEF-G1
GeneCards (Weizmann)GFM1
Ensembl hg19 (Hinxton)ENSG00000168827 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168827 [Gene_View]  ENSG00000168827 [Sequence]  chr3:158644528-158692571 [Contig_View]  GFM1 [Vega]
ICGC DataPortalENSG00000168827
TCGA cBioPortalGFM1
AceView (NCBI)GFM1
Genatlas (Paris)GFM1
WikiGenes85476
SOURCE (Princeton)GFM1
Genetics Home Reference (NIH)GFM1
Genomic and cartography
GoldenPath hg38 (UCSC)GFM1  -     chr3:158644528-158692571 +  3q25.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GFM1  -     3q25.32   [Description]    (hg19-Feb_2009)
GoldenPathGFM1 - 3q25.32 [CytoView hg19]  GFM1 - 3q25.32 [CytoView hg38]
ImmunoBaseENSG00000168827
Mapping of homologs : NCBIGFM1 [Mapview hg19]  GFM1 [Mapview hg38]
OMIM606639   609060   
Gene and transcription
Genbank (Entrez)AF309777 AF367998 AK000780 AK022724 AK023694
RefSeq transcript (Entrez)NM_001308164 NM_001308166 NM_024996
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GFM1
Cluster EST : UnigeneHs.518355 [ NCBI ]
CGAP (NCI)Hs.518355
Alternative Splicing GalleryENSG00000168827
Gene ExpressionGFM1 [ NCBI-GEO ]   GFM1 [ EBI - ARRAY_EXPRESS ]   GFM1 [ SEEK ]   GFM1 [ MEM ]
Gene Expression Viewer (FireBrowse)GFM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)85476
GTEX Portal (Tissue expression)GFM1
Human Protein AtlasENSG00000168827-GFM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RP9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RP9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RP9
Splice isoforms : SwissVarQ96RP9
PhosPhoSitePlusQ96RP9
Domaine pattern : Prosite (Expaxy)G_TR_1 (PS00301)    G_TR_2 (PS51722)   
Domains : Interpro (EBI)EFG_III    EFG_III/V    EFG_V    EFG_V-like    EFTu-like_2    G_TR_CS    P-loop_NTPase    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr    Small_GTP-bd_dom    TF_GTP-bd_dom    Transl_B-barrel_sf    Transl_elong_EFG/EF2    Transl_elong_EFG/EF2_IV   
Domain families : Pfam (Sanger)EFG_C (PF00679)    EFG_IV (PF03764)    GTP_EFTU (PF00009)    GTP_EFTU_D2 (PF03144)   
Domain families : Pfam (NCBI)pfam00679    pfam03764    pfam00009    pfam03144   
Domain families : Smart (EMBL)EFG_C (SM00838)  EFG_IV (SM00889)  
Conserved Domain (NCBI)GFM1
DMDM Disease mutations85476
Blocks (Seattle)GFM1
SuperfamilyQ96RP9
Human Protein Atlas [tissue]ENSG00000168827-GFM1 [tissue]
Peptide AtlasQ96RP9
IPIIPI00154473   IPI00945964   IPI00026321   IPI00788871   IPI00976660   IPI00955800   IPI00944961   
Protein Interaction databases
DIP (DOE-UCLA)Q96RP9
IntAct (EBI)Q96RP9
FunCoupENSG00000168827
BioGRIDGFM1
STRING (EMBL)GFM1
ZODIACGFM1
Ontologies - Pathways
QuickGOQ96RP9
Ontology : AmiGORNA binding  translation elongation factor activity  translation elongation factor activity  GTPase activity  GTPase activity  protein binding  GTP binding  mitochondrion  mitochondrial matrix  mitochondrial translational elongation  mitochondrial translational elongation  mitochondrial translational elongation  
Ontology : EGO-EBIRNA binding  translation elongation factor activity  translation elongation factor activity  GTPase activity  GTPase activity  protein binding  GTP binding  mitochondrion  mitochondrial matrix  mitochondrial translational elongation  mitochondrial translational elongation  mitochondrial translational elongation  
NDEx NetworkGFM1
Atlas of Cancer Signalling NetworkGFM1
Wikipedia pathwaysGFM1
Orthology - Evolution
OrthoDB85476
GeneTree (enSembl)ENSG00000168827
Phylogenetic Trees/Animal Genes : TreeFamGFM1
HOGENOMQ96RP9
Homologs : HomoloGeneGFM1
Homology/Alignments : Family Browser (UCSC)GFM1
Gene fusions - Rearrangements
Fusion : QuiverGFM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGFM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GFM1
dbVarGFM1
ClinVarGFM1
1000_GenomesGFM1 
Exome Variant ServerGFM1
ExAC (Exome Aggregation Consortium)ENSG00000168827
GNOMAD BrowserENSG00000168827
Varsome BrowserGFM1
Genetic variants : HAPMAP85476
Genomic Variants (DGV)GFM1 [DGVbeta]
DECIPHERGFM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGFM1 
Mutations
ICGC Data PortalGFM1 
TCGA Data PortalGFM1 
Broad Tumor PortalGFM1
OASIS PortalGFM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGFM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGFM1
Mutations and Diseases : HGMDGFM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GFM1
DgiDB (Drug Gene Interaction Database)GFM1
DoCM (Curated mutations)GFM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GFM1 (select a term)
intoGenGFM1
Cancer3DGFM1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606639    609060   
Orphanet
DisGeNETGFM1
MedgenGFM1
Genetic Testing Registry GFM1
NextProtQ96RP9 [Medical]
TSGene85476
GENETestsGFM1
Target ValidationGFM1
Huge Navigator GFM1 [HugePedia]
snp3D : Map Gene to Disease85476
BioCentury BCIQGFM1
ClinGenGFM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD85476
Chemical/Pharm GKB GenePA134971637
Clinical trialGFM1
Miscellaneous
canSAR (ICR)GFM1 (select the gene name)
DataMed IndexGFM1
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGFM1
EVEXGFM1
GoPubMedGFM1
iHOPGFM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:44:44 CET 2019
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