GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2)

2019-04-01  

Identity

HGNC
GGA2
LOCATION
16p12.2
LOCUSID
23062
ALIAS
VEAR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23062
MIM: 606005
HGNC: 16064
Ensembl: ENSG00000103365

Variants:

dbSNP: 23062
ClinVar: 23062
TCGA: ENSG00000103365
COSMIC: GGA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103365ENST00000309859Q9UJY4
ENSG00000103365ENST00000562117I3L263
ENSG00000103365ENST00000562944I3L2C4
ENSG00000103365ENST00000563047H3BPF4
ENSG00000103365ENST00000563494H3BMN6
ENSG00000103365ENST00000567468H3BMM6
ENSG00000103365ENST00000569189H3BMN6
ENSG00000103365ENST00000569300H3BPI3
ENSG00000103365ENST00000570111H3BMN6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
156157122005GGA proteins mediate the recycling pathway of memapsin 2 (BACE).108
174948682007PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.66
121357642002Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.47
175965112007The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.27
174515582007The role of cargo proteins in GGA recruitment.15
222919152012Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development.10
197887412009Defects in cellular sorting and retroviral assembly induced by GGA overexpression.8
244072852014Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.7
279010632016Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.7
282892072017Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network.6

Citation

Dessen P

GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57890/gga2