GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3)

2014-11-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23163
MIM: 606006
HGNC: 17079
Ensembl: ENSG00000125447

Variants:

dbSNP: 23163
ClinVar: 23163
TCGA: ENSG00000125447
COSMIC: GGA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125447ENST00000537686Q9NZ52
ENSG00000125447ENST00000538886Q9NZ52
ENSG00000125447ENST00000577435G3V1K5
ENSG00000125447ENST00000578348Q9NZ52
ENSG00000125447ENST00000578773J3QRK7
ENSG00000125447ENST00000579743A0A087WYN2
ENSG00000125447ENST00000580646J3QS87
ENSG00000125447ENST00000580799J3KSG3
ENSG00000125447ENST00000582376J3QRS8
ENSG00000125447ENST00000582486J3KSS7
ENSG00000125447ENST00000582717Q9NZ52
ENSG00000125447ENST00000583282J3KTR5
ENSG00000125447ENST00000584243J3QRP3
ENSG00000125447ENST00000584550J3KS27
ENSG00000125447ENST00000621217B7Z1E9
ENSG00000125447ENST00000621870G3V1K5
ENSG00000125447ENST00000649398Q9NZ52

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Signaling by METREACTOMER-HSA-6806834
MET receptor recyclingREACTOMER-HSA-8875656
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175534222007Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.172
156157122005GGA proteins mediate the recycling pathway of memapsin 2 (BACE).108
150397752004Interactions of GGA3 with the ubiquitin sorting machinery.90
174948682007PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.66
118593752002Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.63
204840532010Ubiquitin regulates GGA3-mediated degradation of BACE1.44
169773092006A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.29
157016882005Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins.25
154944132004The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs.24
198155562009Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.18

Citation

Dessen P

GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63765/gga3