GGCT (gamma-glutamylcyclotransferase)

2007-08-01  

Identity

HGNC
GGCT
LOCATION
7p14.3
LOCUSID
79017
ALIAS
C7orf24,CRF21,GCTG,GGC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79017
MIM: 137170
HGNC: 21705
Ensembl: ENSG00000006625

Variants:

dbSNP: 79017
ClinVar: 79017
TCGA: ENSG00000006625
COSMIC: GGCT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006625ENST00000005374O75223
ENSG00000006625ENST00000275428O75223
ENSG00000006625ENST00000275428A0A090N7V5
ENSG00000006625ENST00000409144O75223
ENSG00000006625ENST00000409390O75223
ENSG00000006625ENST00000409436B8ZZK2
ENSG00000006625ENST00000426081H7BZK5
ENSG00000006625ENST00000440082A0A0B4J1Y4
ENSG00000006625ENST00000447901A0A0B4J1Y4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185153542008The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.35
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
204069642010Risk of meningioma and common variation in genes related to innate immunity.12
205279792010Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker.12
258180032015Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis.12
167659122006A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol.9
243424342014γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.8
222056822012Widespread expression of γ-glutamyl cyclotransferase suggests it is not a general tumor marker.6
263396072015Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment.6
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.5

Citation

Dessen P

GGCT (gamma-glutamylcyclotransferase)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47695/ggct