GGPS1 (geranylgeranyl diphosphate synthase 1)

2021-06-01  

Identity

HGNC
LOCATION
1q42.3
LOCUSID
ALIAS
GGPPS,GGPPS1

Other Information

Locus ID:

NCBI: 9453
MIM: 606982
HGNC: 4249
Ensembl: ENSG00000152904

Variants:

dbSNP: 9453
ClinVar: 9453
TCGA: ENSG00000152904
COSMIC: GGPS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152904ENST00000282841O95749
ENSG00000152904ENST00000282841A0A024R3W4
ENSG00000152904ENST00000358966O95749
ENSG00000152904ENST00000358966A0A024R3W4
ENSG00000152904ENST00000391855O95749
ENSG00000152904ENST00000471812C9J7M1
ENSG00000152904ENST00000488594O95749
ENSG00000152904ENST00000488594A0A024R3W4
ENSG00000152904ENST00000497327C9J6G3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Terpenoid backbone biosynthesisKEGGko00900
Terpenoid backbone biosynthesisKEGGhsa00900
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Cholesterol biosynthesisREACTOMER-HSA-191273
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166987912006The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.41
213211122011An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism.31
212240492011Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling.15
234785742013Egr-1 enhances drug resistance of breast cancer by modulating MDR1 expression in a GGPPS-independent manner.13
247167912014GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis.9
84193601993Distribution of prenyltransferases in rat tissues. Evidence for a cytosolic all-trans-geranylgeranyl diphosphate synthase.8
176461722007Human geranylgeranyl diphosphate synthase is an octamer in solution.8
284678652017GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.6
201910152010Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women.5
201910152010Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women.5

Citation

Dessen P

GGPS1 (geranylgeranyl diphosphate synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58195/ggps1