GGT2 (gamma-glutamyltransferase 2)

2018-11-01 Affiliation

Identity

HGNC

GGT2

LOCATION

22q11.21

LOCUSID

728441

ALIAS

GGT,GGT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 728441
MIM: 137181
HGNC: 4251
Ensembl: ENSG00000133475

Variants:

dbSNP: 728441
ClinVar: 728441
TCGA: ENSG00000133475
COSMIC: GGT2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133475	ENST00000401924	P36268
ENSG00000133475	ENST00000405188	B5MCK8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)	REACTOME	R-HSA-2142691
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Glutathione synthesis and recycling	REACTOME	R-HSA-174403
Aflatoxin activation and detoxification	REACTOME	R-HSA-5423646

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22269385	2012	K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2.	9
25280803	2014	Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.	7
17976673	2008	Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility.	3
19012630	2008	The population distributions, upper normal limits and correlations between liver tests among Australian adolescents.	3
25180444	2015	Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.	3
18071669	2008	Can persistent organic pollutants explain the association between serum gamma-glutamyltransferase and type 2 diabetes?	0
18297606	2008	Plasma glutathione levels are independently associated with gamma-glutamyltransferase activity in subjects with cardiovascular risk factors.	0
18342385	2008	Relationship between response of gamma-glutamyltransferase to alcohol consumption and levels of fasting plasma glucose.	0
18421185	2008	Plasma gamma-glutamyl transferase activity predicts homocysteine concentration in a large cohort of unselected outpatients.	0
18486136	2009	Gamma-glutamyltransferase activity in human atherosclerotic plaques--biochemical similarities with the circulating enzyme.	0

Citation

Dessen P

GGT2 (gamma-glutamyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57716/ggt2