GH2 (growth hormone 2)

2007-02-01 Affiliation

Identity

HGNC

GH2

LOCATION

17q23.3

LOCUSID

2689

ALIAS

GH-V,GHB2,GHL,GHV,hGH-V

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2689
MIM: 139240
HGNC: 4262
Ensembl: ENSG00000136487

Variants:

dbSNP: 2689
ClinVar: 2689
TCGA: ENSG00000136487
COSMIC: GH2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000136487	ENST00000332800	P01242
ENSG00000136487	ENST00000423893	P01242
ENSG00000136487	ENST00000423893	A0A0M6L0J9
ENSG00000136487	ENST00000449787	P01242
ENSG00000136487	ENST00000456543	P01242
ENSG00000136487	ENST00000622506	A0A087WXJ5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Neuroactive ligand-receptor interaction	KEGG	ko04080
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Jak-STAT signaling pathway	KEGG	hsa04630
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Growth hormone receptor signaling	REACTOME	R-HSA-982772
Prolactin receptor signaling	REACTOME	R-HSA-1170546

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
20403354	2010	A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence.	30
12946357	2003	The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.	17
15718272	2005	Stimulation of human trophoblast invasion by placental growth hormone.	17
17701665	2007	Placental growth hormone is increased in the maternal and fetal serum of patients with preeclampsia.	16
15563602	2004	The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.	12
15531513	2004	Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster.	11
22387044	2012	Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.	9
11994274	2002	Autocrine human growth hormone inhibits placental transforming growth factor-beta gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells.	8
18356738	2008	Regulation of placental growth hormone secretion in a human trophoblast model--the effects of hormones and adipokines.	6
22363400	2012	Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.	6

Citation

Dessen P

GH2 (growth hormone 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45698/gh2