GHSR (growth hormone secretagogue receptor)

2007-02-01 Affiliation

Identity

HGNC

GHSR

LOCATION

3q26.31

LOCUSID

2693

ALIAS

GHDP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2693
MIM: 601898
HGNC: 4267
Ensembl: ENSG00000121853

Variants:

dbSNP: 2693
ClinVar: 2693
TCGA: ENSG00000121853
COSMIC: GHSR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000121853	ENST00000241256	Q92847
ENSG00000121853	ENST00000427970	Q92847

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA448073	ethanol	Chemical	VariantAnnotation	associated			18828808

References

Pubmed ID	Year	Title	Citations
8688086	1996	A receptor in pituitary and hypothalamus that functions in growth hormone release.	250
15232612	2004	Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.	198
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16511605	2006	Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.	68
15383539	2004	Common structural basis for constitutive activity of the ghrelin receptor family.	67
12045256	2002	Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.	46
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
23161547	2013	Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.	43
22117076	2012	High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs.	36
14763915	2004	Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines.	34

Citation

Dessen P

GHSR (growth hormone secretagogue receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46445/ghsr