GINS2 (GINS complex subunit 2)

2011-03-01  

Identity

HGNC
LOCATION
16q24.1
LOCUSID
ALIAS
HSPC037,PSF2,Pfs2
FUSION GENES

Other Information

Locus ID:

NCBI: 51659
MIM: 610609
HGNC: 24575
Ensembl: ENSG00000131153

Variants:

dbSNP: 51659
ClinVar: 51659
TCGA: ENSG00000131153
COSMIC: GINS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131153ENST00000253462Q9Y248
ENSG00000131153ENST00000595355M0R043
ENSG00000131153ENST00000596233M0QXS3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
GINS complexKEGGhsa_M00286
GINS complexKEGGM00286
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224743842012Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.66
210820432010Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2.18
284056872017GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer.15
242734542013Effect of GINS2 on proliferation and apoptosis in leukemic cell line.12
278295492016GINS2 regulates matrix metallopeptidase 9 expression and cancer stem cell property in human triple negative Breast cancer.12
253484322014High GINS2 transcript level predicts poor prognosis and correlates with high histological grade and endocrine therapy resistance through mammary cancer stem cells in breast cancer patients.7
301778192019GINS2 promotes cell proliferation and inhibits cell apoptosis in thyroid cancer by regulating CITED2 and LOXL2.5
235890402013Roles of GINS2 in K562 human chronic myelogenous leukemia and NB4 acute promyelocytic leukemia cells.3
280717572017New insights into the GINS complex explain the controversy between existing structural models.3
303386502019Loss of GINS2 inhibits cell proliferation and tumorigenesis in human gliomas.3

Citation

Dessen P

GINS2 (GINS complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52149/gins2