GINS4 (GINS complex subunit 4)

2015-04-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
SLD5
FUSION GENES

Other Information

Locus ID:

NCBI: 84296
MIM: 610611
HGNC: 28226
Ensembl: ENSG00000147536

Variants:

dbSNP: 84296
ClinVar: 84296
TCGA: ENSG00000147536
COSMIC: GINS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147536ENST00000276533Q9BRT9
ENSG00000147536ENST00000518671Q9BRT9
ENSG00000147536ENST00000520354E5RH56
ENSG00000147536ENST00000520710Q9BRT9
ENSG00000147536ENST00000523277E5RFF9

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
GINS complexKEGGhsa_M00286
GINS complexKEGGM00286
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174176532007Structure of the human GINS complex and its assembly and functional interface in replication initiation.34
274992482016Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells.9
312531902019LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.6
280717572017New insights into the GINS complex explain the controversy between existing structural models.3
275920302016GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication.2
304136052018Up-regulated and interrelated expressions of GINS subunits predict poor prognosis in hepatocellular carcinoma.2
290617322018Sld5 Ensures Centrosomal Resistance to Congression Forces by Preserving Centriolar Satellites.1
320123892020GINS complex subunit 4, a prognostic biomarker and reversely mediated by Krüppel-like factor 4, promotes the growth of colorectal cancer.1

Citation

Dessen P

GINS4 (GINS complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-04-01

Online version: http://atlasgeneticsoncology.org/gene/55151/gins4