GIP (gastric inhibitory polypeptide)

2003-11-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 2695
MIM: 137240
HGNC: 4270
Ensembl: ENSG00000159224

Variants:

dbSNP: 2695
ClinVar: 2695
TCGA: ENSG00000159224
COSMIC: GIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159224ENST00000357424P09681

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)REACTOMER-HSA-400511
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230640142012A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.77
149882492004Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.45
172446062007Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade.43
201380412010Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion.40
202003052010Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide.39
180545522007Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation.33
200080192010Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men.32
197488892009Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide.31
204680642010Association study of 182 candidate genes in anorexia nervosa.30
245250202014Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans.29

Citation

Dessen P

GIP (gastric inhibitory polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40713/gip