GIPR (gastric inhibitory polypeptide receptor)

2009-09-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
PGQTL2
FUSION GENES

Other Information

Locus ID:

NCBI: 2696
MIM: 137241
HGNC: 4271
Ensembl: ENSG00000010310

Variants:

dbSNP: 2696
ClinVar: 2696
TCGA: ENSG00000010310
COSMIC: GIPR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000010310ENST00000263281P48546
ENSG00000010310ENST00000304207P48546
ENSG00000010310ENST00000585889K7EPD9
ENSG00000010310ENST00000590918P48546
ENSG00000010310ENST00000591322K7EJZ3
ENSG00000010310ENST00000652180A0A494C077

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD21747410, 25321336
PA450688olanzapineChemicalClinicalAnnotationassociatedPD21747410, 25321336

References

Pubmed IDYearTitleCitations
200818572010Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.262
200818572010Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.262
201858072010Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.101
193866262009Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.90
151115032004Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.55
224129062012Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.21
222370642012Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial.20
192116862009Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.18
223995042012Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.18
245124892014Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance.17

Citation

Dessen P

GIPR (gastric inhibitory polypeptide receptor)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51056/gipr