GLIPR1 (GLI pathogenesis related 1)

2003-02-01  

Identity

HGNC
LOCATION
12q21.2
LOCUSID
ALIAS
CRISP7,GLIPR,RTVP1

Other Information

Locus ID:

NCBI: 11010
MIM: 602692
HGNC: 17001
Ensembl: ENSG00000139278

Variants:

dbSNP: 11010
ClinVar: 11010
TCGA: ENSG00000139278
COSMIC: GLIPR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139278ENST00000266659P48060
ENSG00000139278ENST00000456650F6VVE8
ENSG00000139278ENST00000536703B4E3S5
ENSG00000139278ENST00000550491J3QTC9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
237146872013MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1.94
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
181995372008Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling.25
148718272004RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer.24
180303652007Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors.20
167140932006Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.16
220255622011GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.13
219312162011Structural studies of human glioma pathogenesis-related protein 1.12
233335972013Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

GLIPR1 (GLI pathogenesis related 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40721/glipr1