GLRA2 (glycine receptor alpha 2)

2016-10-01  

Identity

HGNC
LOCATION
Xp22.2
LOCUSID
ALIAS
GLR
FUSION GENES

Other Information

Locus ID:

NCBI: 2742
MIM: 305990
HGNC: 4327
Ensembl: ENSG00000101958

Variants:

dbSNP: 2742
ClinVar: 2742
TCGA: ENSG00000101958
COSMIC: GLRA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101958ENST00000218075P23416
ENSG00000101958ENST00000355020P23416
ENSG00000101958ENST00000415367C9JBL4
ENSG00000101958ENST00000443437P23416

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
161448312005Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.38
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
202372952010Lysophosphatidylcholine increases neutrophil bactericidal activity by enhancement of azurophil granule-phagosome fusion via glycine.GlyR alpha 2/TRPM2/p38 MAPK signaling.20
151475102004Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism.16
273820602016Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.4
226063112012Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits.3

Citation

Dessen P

GLRA2 (glycine receptor alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56348/glra2