GLTP (glycolipid transfer protein)

2014-11-01  

Identity

HGNC
GLTP
LOCATION
12q24.11
LOCUSID
51228
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51228
MIM: 608949
HGNC: 24867
Ensembl: ENSG00000139433

Variants:

dbSNP: 51228
ClinVar: 51228
TCGA: ENSG00000139433
COSMIC: GLTP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139433ENST00000318348Q9NZD2
ENSG00000139433ENST00000318348A0A024RBI7
ENSG00000139433ENST00000536390F5GZ49
ENSG00000139433ENST00000537066F5GZ49
ENSG00000139433ENST00000540772H0YFS9
ENSG00000139433ENST00000544393F5H0U5
ENSG00000139433ENST00000617457F5GZ49

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
153297262004Structural basis for glycosphingolipid transfer specificity.48
159017392005Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex.23
106715542000Cloning and expression of glycolipid transfer protein from bovine and porcine brain.22
152877562004Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy.18
106536522000Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers.17
155040432004Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses.17
192703382009Glycolipid acquisition by human glycolipid transfer protein dramatically alters intrinsic tryptophan fluorescence: insights into glycolipid binding affinity.15
196659982009The glycolipid transfer protein interacts with the vesicle-associated membrane protein-associated protein VAP-A.13
209591042010Human GLTP: Three distinct functions for the three tryptophans in a novel peripheral amphitropic fold.12
182612242008Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution.10

Citation

Dessen P

GLTP (glycolipid transfer protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63833/gltp