GLUD1 (glutamate dehydrogenase 1)

2013-12-01  

Identity

HGNC
LOCATION
10q23.2
LOCUSID
ALIAS
GDH,GDH1,GLUD
FUSION GENES

Other Information

Locus ID:

NCBI: 2746
MIM: 138130
HGNC: 4335
Ensembl: ENSG00000148672

Variants:

dbSNP: 2746
ClinVar: 2746
TCGA: ENSG00000148672
COSMIC: GLUD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148672ENST00000277865P00367
ENSG00000148672ENST00000277865E9KL48

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
D-Glutamine and D-glutamate metabolismKEGGko00471
Nitrogen metabolismKEGGko00910
Arginine biosynthesisKEGGhsa00220
D-Glutamine and D-glutamate metabolismKEGGhsa00471
Nitrogen metabolismKEGGhsa00910
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198260362009Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.164
206597892010Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.85
256700812015Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.71
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
153780632004Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.67
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
201642122010Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations.35
198900032009Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.32
235077042013Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer.32

Citation

Dessen P

GLUD1 (glutamate dehydrogenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53627/glud1